A deadly flood has struck communities along the Nepal-Tibet border, with hundreds of people reportedly unaccounted for following heavy rainfall in the mountainous region.

The flooding caused widespread destruction, sweeping away homes, roads and other infrastructure while cutting off access to some affected communities.

Rescue and emergency teams have been mobilised to search for missing residents and provide assistance to those affected by the disaster.

Authorities have also faced difficulties reaching some areas because landslides and damaged roads have disrupted transportation and communications.

The disaster has raised concerns about the safety of residents living in remote communities along the border, where heavy rainfall can rapidly trigger floods and landslides.

Officials are continuing to assess the damage and establish the number of casualties as rescue operations progress.

Families of missing residents have gathered at emergency centres and other locations while authorities work to locate those who remain unaccounted for.

The incident has also prompted renewed concerns over the vulnerability of communities in Nepal's mountainous regions to extreme weather and natural disasters.

Authorities have urged residents in vulnerable areas to remain alert and follow evacuation instructions as rescue and recovery efforts continue.